Too early to start planning for the holiday season? Nonsense. Due to COVID-19, online purchasing is up 28%, and the landscape of shopping, in general, will look much different this year.
Some of us are always ahead of the game and trying to capture the best deals, while others are the last second gift-buyers. But regardless of whatever category you typically fall under, you’re going to want to be the former instead of the latter this year and we’re here to tell you why.
Shipping. Shipping. Shipping.
From lost packages to avoiding face-to-face deliveries, shipping has been a nightmare during the pandemic. Currently, shipping carriers have announced that they are already delivering at peak holiday numbers and they are estimated to be at a 5% over capacity. So, how do you beat this? Shop early and allow your order time to arrive so you do not unintentionally gain a part-time job tracking your own packages.
Out of Stock Products
Traditionally, Black Friday marks the unofficial start of the holiday season, but it is no secret now that the sale season will be kicking off as soon as mid-October. This means that some of the biggest deals and best-sellers may be short in inventory the longer you wait! If you decide to try and play the dangerous game of buying at the last second, you may end up being the person handing out gifts weeks after the holidays.
Avoiding Busy Shopping Center
For obvious reasons, brick-and-mortar shopping has become a tricky situation and it will only get more challenging when tons of people swarm to the malls around you! Whether it’s in the form of waiting in lines out in the cold or being in uncomfortably packed department stores, there’s so many reasons to avoid or at least limit the amount of time spent shopping at the mall.
The holidays are already a stressful time. With so many additional stressors, do not make the season any harder than it must be! Get ahead with your planning, keep yourself and those around you healthy and enjoy being with your family.
David Aizer, a South Florida TV personality who has hosted TV shows for Nickelodeon, CBS, The CW, Fox Sports and more, has taken his stage III Melanoma and turned it into a tool to motivate and inspire others. His five-year journey through PET scans, brain MRI’s, CAT scans, a two-year clinical trial, numerous vials of blood and constant anxiety showed him that everyone has two options in life:
Be scared, angry and self-conscious about the challenges you’re facing.
Embrace life’s challenges and be grateful.
He recently gave a motivational TEDx Talk where he challenged everyone to look at their battle scars, whatever they may be, and realize that they’re part of what makes you, you. Every scar is an opportunity to educate, motivate and inspire others. It’s a great listen for anyone, no matter the diversity you’ve faced in your life.
David also wrote a memoir about his experience. His first-person account of how battling melanoma impacted him is full of honesty and heart. His ability to look back, reflect and find the humor in his experience is something we all need. Be ready to laugh and cry, then call your doctor.
If you follow us on Instagram, you have most likely seen us share dozens of Stories with our followers wearing their UPF 50+ gloves. To some, this may look or seem completely ridiculous to wear gloves while driving, but there is a lot of reasoning behind the logic of wearing them!
The average driver in the U.S. spends 17,600 minutes in their car each year, according to the AAA Foundation for Traffic Safety. That is 293 hours! With all that potential sun exposure, your hands and arms suffer the most and are typically exposed to more UV rays while driving that most other parts of your body.
Even with all that time in your vehicle, you may feel like your car offers a lot of protection from the sun, but for the most part, that is just not true. Your windshield may block some UV rays, but your door windows offer minimal protection. An interesting, but true statistic is that typically the left side of our bodies show more sun-related aging because of the time spent driving!
So that brings us to the point of the entire blog… Why should I wear them? The answer is simple: To protect your hands from unnecessary sun exposure that leads to aging, wrinkly skin and skin cancer.
From fingerless to sleeves, we offer a variety of gloves that can fit your preference and need!
Looking for the classic driving coverage? These are perfect!
For those that want a little more extended coverage:
It’s no secret that the most effective protection against the sun is the protection that you wear.
Ever heard of sunscreen? Of course you have. It’s been around for nearly 90 years. It’s a good form of protection from the sun, but there is one catch to its effectiveness – It must be reapplied every two hours. Sunscreen paired with other forms of protection works wonders, but alone it’s just not enough. For that reason, you won’t find any products with SPF in our top 5.
UPF 50+ clothing and accessories, on the other hand, provide the most effective form of sun protection because there not as much of a commitment as sunscreen ends up being, won’t wash off due to water or sweat, and always applies to UVB and UVA rays.
Still trying to figure out the difference between UPF and SPF? Check out our blog on it.
Follow these 5 tips to protect your skin from the sun’s rays.
1. Wear a wide-brimmed hat
Choose a hat with a 3-inch or greater brim to protect your face, scalp, ears and neck.
2. Switch Out Everyday Favorites
Swap everyday favorites for long sleeve UPF 50+ shirts.
3. Add UPF 50+ Coverage
Add coverage to short sleeves when lounging outdoors or performing workouts.
4. Protect Over-Exposed Hands
Keep a spare pair of UPF 50+ gloves in your car to protect your hands.
5. Use Sun Blankets for On-the-Go
Pack a UPF 50+ sun blanket for handy sun protection when you’re out and about.
Did you know there’s a difference between SPF and UPF? Both have something to do with keeping your skin protected from the sun but mean very different things. Sunlight includes rays of invisible ultraviolet (UV) radiation; overexposure to UV rays can lead to sunburn, accelerated skin aging and skin cancer. Sun protective clothing and sunscreen offer your main forms of UV protection but are rated two different ways with SPF and UPF.
UPF is the standard used to measure the effectiveness of sun protective fabrics. UPF stands for “Ultraviolet Protection Factor” and indicates how much of the sun’s UV radiation penetrates a fabric and reaches the skin. UPF is associated with fabric and you will see a UPF rating from 15-50 associated with products that claim that they are sun protective. A fabric with a rating of 50 will allow only 1/50th of the sun’s UV rays to pass through. This means the fabric will reduce your skin’s UV radiation exposure significantly because only 2 percent of the UV rays will get through. This also means that it blocks both UVA and UVB rays while SPF only takes the UVB rays into account.
SPF is a standard used to measure the effectiveness of sunscreen. SPF stands for “Sun Protection Factor”. It measures the amount of time it takes for sun-exposed skin to redden, while UPF measures the amount of UV radiation that penetrates a fabric and reaches the skin. Remember that SPF only accounts for UVB rays unless specifically stated as a broad-spectrum sunscreen.
Here is a visual breakdown of the two compared to each other.
As you can see when you are trying to keep your skin protected it is important to know the different rating systems. Many skin-care experts believe clothing shields skin more effectively from UV light than sunscreen. Many of us often apply sunscreen lotions too thinly, giving our skin less protection than the sunscreen’s available SPF rating, and we neglect to reapply it as directed by the specific sunscreen that we use.
To receive The Skin Cancer Foundation’s Seal of Recommendation, sun-protective fabrics must have a minimum UPF of 30. They consider a UPF rating of 30-49 to offer very good protection and 50+ excellent protection. Coolibar was the first clothing brand to receive the Skin Cancer Foundation’s Seal of Recommendation. All of our clothing is rated UPF 50+, with protection that will never wash out.
Warriors Advocate for Skin Cancer Prevention and Protection During a Pandemic
Coolibar launched This is Brave in 2018 when a young girl stepped up and reminded us all of the importance of advocating for and supporting individuals with skin cancer. When Quinn told her brother Graham to Be Brave, she was reminding us all that we can do this! We can battle through and no matter what the outcome might be, we’re better when we can Be Brave together.
In 2020, the third year of our This is Brave campaign and first year as the Official Apparel Partner of the Melanoma Research Foundation (MRF), our mission remains the same but the need for support is even greater. In the past few months, the world has shifted significantly in terms of patient care, research funding, and non-profit outreach. Key fundraising events like Miles for Melanoma have been postponed, and we’re working with the MRF and our community to find ways to continue funding life-saving research, and support patients and advocates across the country.
One in five Americans will develop skin cancer in their lifetime whether there is a pandemic or not. #CancerHasNoCurve. The good news, the MRF and the greater melanoma community continues to be strong and active. Patients and advocates have done everything from taking the message of prevention and protection cross-country, to telling a neighbor to care for their skin and get checked. You are amazing. Everything you’re doing counts!
A lot will change forever in 2020, but the need for skin cancer prevention and protection will not. If you’re able, we’re asking you to support skin cancer awareness and the MRF this May, Melanoma Awareness Month. Here is how you can help:
Read the awe-inspiring stories of our Brave warriors and share them with your friends and family. Awareness can save lives!
Consider donating to the MRF. They’ve created wonderful virtual programs to ensure that the funding for research and education remains strong.
Purchase a 2020 This is Brave UPF 50+ T-Shirt for yourself or send it to someone as a sun-safe gift for a cause. The proceeds go directly to the MRF.
Thank you for all that you do and remember…together we can BE BRAVE!
As long as I could remember, I’d had a red spot on the white of my left eye. In my late teens, it started to grow, change and become raised and irritating. After years of following this up with my general practitioner, I finally got referred to an ophthalmologist when I was 20. He did a biopsy, which came back benign (non-cancerous). Six months later, three very dark spots that resembled a skin mole grew on the same eye. I had the second biopsy done on these new spots and was officially diagnosed with conjunctival ocular melanoma at the age of 21 in January 2015.
When I was told I had ocular melanoma, the room became blurry, an overwhelming sea of emotion and fear came over me and drowned out everything he said following my diagnosis. Cancer, on my eye?! Can that even happen? Isn’t cancer for old people? Is my life basically over now? It had barely begun!
I felt nauseous, trapped and confused. I didn’t feel or look sick so how could my life potentially be on the line? I wondered how long it would be until this illness caught up with me and actually made me look and feel unwell. However, a few weeks passed, and nothing really changed.
I had a lot of check-ups until they informed me that my treatment plan would be watching and waiting. No chemo, no radiation, nothing. I was so confused. Grateful, but confused. It almost felt anticlimactic, such a scary diagnosis and yet all I needed to do was see my oncologist every six weeks.
Six months went by during which I had more biopsies which all came back benign. We started to relax, my appointments became less frequent and life went back to normal. Then, what felt like it happened overnight, I noticed five new spots on the white of my eye and a small lump underneath my eyelid in August 2015. I went to my general practitioner first and he called my ophthalmic oncologist’s office right away. I was booked in to see him a few days later.
I could tell my oncologist felt unsettled at this appointment, he didn’t like what he was seeing and booked another biopsy. All the new spots he removed came back positive for malignant melanoma. This was when the tune changed. Things escalated quickly and I was being told I was going to have to lose my eye and eyelids, and that they’d close over the socket for good in order to save my life.
I still remember the pain and anger I felt in the moment. The very normal life I had imagined for myself—the typical, all-American family life with a husband, a house and a great career—was ripped away in that moment. I went home that night and thought about my options. Very quickly, I realised that I would do whatever it took to save my life. The only real choice I had was whether or not I’d let this break me. Would I hide away from the world or would I find a way to embrace it?
Well, within a few days, I decided I wanted to embrace this new look and make it my own. I went online and found beautiful, bright eye-patches that were going to be my fabulous new fashion accessory. It took me less than 24-hours to embrace my diagnosis and the opportunities it presented.
On October 9th, 2015 I had an exenteration—complete surgical removal of my eye and the contents of my eye socket. The first few days I was in a lot of pain. I couldn’t keep food down and I slept in 90-minute cycles. On the fifth day I had the dressing taken off and got to see my new look for the first time. To best describe how I felt, I’ve taken an excerpt from my book Eye Won: Powerfully Positive, Ridiculously Resilient…
“I almost bounded out of bed to see my new face. I expected to see someone foreign staring back at me, but I saw my bright familiar smile, my freckled cheeks, my button nose, my on-point eyebrows. The only difference, there was one eye staring back not two.”
I analyzed my face and saw a soft beauty in it and my smile brightened as I accepted the woman in the mirror as me. I silently told her that she was beautiful, strong, courageous and most importantly…still me. I tried out my new eye-patches and explored the world a little, embracing my new fashion accessory.
Life quickly went back to normal. Within a month, I was working, driving, studying and socializing. The only thing that had changed was I had a fun new accessory, my eye patch. Most importantly, it looked like we had eradicated the cancer! While the surgery had been challenging both physically and emotionally, I was grateful we’d done it and I could go back to living life as a twenty-something-year-old woman.
On September 9th, 2016 I remember sitting at home with my mum planning out how we were going to celebrate my first annual eye-versary when I had a seizure. I was raced to the hospital and told that the melanoma had spread to my brain and had become Stage IV Melanoma. My heart sank, I knew that everything I had faced up until this point had been child’s play in comparison to what I was about to face.
After having brain surgery to remove the cancer, I had to relearn how to walk and start an ipilimumab plus nivolumab (Ipi/Nivo) blend to prevent the development of more tumors. Looking back on that time, I know I felt terror. To get through it, I focused on what I was grateful for, the blessings I had and the things that made me smile.
More than anything else, the overwhelmingly beautiful feeling of gratitude is the first emotion that comes to mind when I think of my cancer journey.
Three and a half years after my brain surgery and I am thankfully still stable. I have such a beautiful appreciation for life and have accomplished so much. I completed my university degree during my treatment for Stage IV Melanoma. I hiked the Kokoda Trail in 2018, exactly two years after taking my first steps. I wrote and published my book Eye Won, which became a best seller in October 2019. And I got engaged to my incredible fiancé!
Cancer has taught me so much about myself and about the world. While it’s not something I would ever wish on anyone else, I would not be the woman I am today without it. For that I am grateful.
October 8th, 2006. I remember the day quite vividly. A week prior, I had been to my dermatologist to have a small bump on my head looked at. Not overly concerned since it didn’t have any of the typical signs of melanoma. My doctor scraped off enough for a biopsy and I went back to work. Then, on October 8th, I was in a conference room and my phone buzzed. It was my dermatologist’s office calling. I excused myself from the meeting and stepped into the hallway to take the call. It was my actual doctor and not the physician’s assistant. After an exchange of pleasantries, she paused, “I got the results of your biopsy. It’s cancerous. You have melanoma”. I was stunned by the gut punch. The rest of the day was a blur. At that moment, my cancer journey had officially begun.
Two months later in December, a surgical oncologist removed the tumor along with some adjacent lymph nodes on both sides of my neck. The tumor was deeper than expected and diagnosed as stage III melanoma, but it was removed. Margins were clear and I had no cancer activity in my lymph nodes. I felt fortunate and believed that I dodged a bullet.
In 2008, after two years of being NED (no evidence of disease), a follow-up routine chest X-ray showed shadowing and spots on my lungs. The melanoma had returned and had reached a stage IV diagnosis. Over the next 18 months, I had three lung surgeries to remove new tumor growths and wedge resection surgeries that took away 25% of my lungs. I tried to stay positive and committed to outrunning the cancer, literally. I took my exercise to a higher level, enhanced an already good diet, and made a conscious effort to mitigate the stress in my life.
After my third lung surgery, I completed 30 days of Interferon treatment (a form of chemo). It was challenging and I’d never felt worse in my life. Despite the steps I’d taken, by May of 2011, a CT scan revealed that I had tumors on both lungs, pancreas, liver and behind my heart. My stage IV diagnosis became more severe.
I met with my oncologist to map out a treatment plan. I wasn’t going down without a fight. Unfortunately, another surgery was not an option and my doctor didn’t know of any clinical trials. Basically, there was no plan. My doctor looked at me and said, “there is nothing more I can do for you”. Those words pierced the air. Emotions ran rampant, but reality had a way of setting in quickly. I had stage IV melanoma and there is no stage V.
After trying to fully comprehend the odds I was up against, I promised myself that I would find someone, somewhere to help. I wanted to give myself the absolute best chance for survival, so I sought out arguably the best place for cancer treatment – MD Anderson in Houston, TX. They are ranked No. 1 in cancer treatment year after year and are known for advanced cancer treatment options.
My wife and I flew from Atlanta to Houston and met with Dr. Patrick Hwu, a highly respected oncologist specializing in melanoma (today he is the Division Head of Cancer Medicine). When we met, it was clear that he had already reviewed my case as he said, “We’ve got a growing number of options in the melanoma treatment toolbox and I think we can help you. It’s never a good time to be diagnosed with melanoma, but if ever there was a time now is it”.
Amongst the options available, we talked a lot about a relatively new treatment category at the time called “immunotherapy” – training the cells of your immune system to seek out and destroy the cancer cells. After weeks and weeks of various testing, certain treatments were ruled out since my cells did not respond. Ultimately, the best option was a clinical immunotherapy trial that combined high dose IL-2 interleukin (a standard of care treatment option for melanoma at the time) with the Mage 3 vaccine. IL-2 by itself had a pretty low rate of response, but the clinical trial was to see if tying it to a vaccine would improve the response rate. The treatment had drawbacks – side effects, physical hardship, mental challenges, a long duration, and of course, the fact that the trial was new and nobody had completed it at that time.
To fulfill the inpatient treatment requirements, I would travel to MD Anderson in Houston for a week at a time, then return home for one to three weeks. I did this for about eight months. The biggest criterion of the trial protocol was that after each week of treatment I underwent a full CT and a brain MRI. If tumors were stable or shrunk, I continued with the trial. If they grew, then I was removed from the trial.
I started the first week of October 2011. The treatment was tough. Each time I was in intensive care hooked up to multiple machines monitoring every vital you can think of. I gained about 40 pounds of water weight each week and then would have to lose it before I was discharged. I experienced uncontrollable chills and muscular spasms. My heart rate would spike into the low 200’s after each dose of IL-2. My taste buds all but disappeared and I hardly ate. Somehow, in the haze of it all, my immune system responded, and my tumors began to slowly shrink. Week after week, month after month, my CT and MRI results showed progress and I kept going back to Houston for treatment.
I finally completed the inpatient portion of the trial over the eight-month period. Although extremely happy to finish, I wasn’t done. I continued head, neck, chest and pelvic CTs and brain MRIs immediately prior to each return trip to Houston. Every three months, then every six months to get lab work done, meet with my research nurse to answer a litany of questions about how I was doing physically and mentally, meet with Dr. Hwu and, of course, get my vaccine. On February 14th, 2014, in Houston for my checkup and scan results, I received the news I had been dreaming about. My scans and MRI showed no tumor activity. I was in remission.
After that landmark day, I continued getting CT scans, MRIs and the vaccines for another year. In July 2015, after 4+ years of countless hours in the ICU and flying back forth from Atlanta to Houston for the vaccine, I become the first patient to complete the IL-2 & MAGE 3 clinical trial.
It’s now May 2020 and I am 13+ years removed from my original melanoma diagnosis. I’ve had a combination of 16 major and minor surgeries. But most importantly…I’ve been cancer-free for six years.
My advice to you after all of this is to accept the facts and realize that no one is immune. More people are diagnosed with skin cancer each year in the U.S. than all other cancers combined.
Melanoma is the third most common cancer among men and women ages 20-39, and on age-related cancers, melanoma is the #1 most diagnosed cancer among 25 to 29-year old’s in the United States. So be smart! PLEASE wear sunscreen and sun protective clothing, check your entire body for changes in your skin and see your dermatologist regularly. Most importantly…enjoy life and take care of your body – it’s the only one you get!
For those still battling cancer – keep the faith, keep fighting and don’t ever give up. Above all, always believe that miracles are possible.
Melanoma is one of the deadliest cancers in the world. When someone becomes diagnosed with melanoma, or any type of cancer, it changes them. It changes not only their world, but the world of their loved ones. There are a lot of feelings that bounce around during that time. A lot of pain, anger, frustration, and fright, but mostly: strength and courage. These feelings, and those changes happened to me when I was diagnosed with melanoma at the age of eighteen.
A lot of people are familiar with my story due to the fact that I was able to use my title and platform, as Miss Illinois USA 2018 to raise awareness, and promote prevention and healthy living. Although people are familiar with the story of my diagnosis, they are oftentimes not familiar with the struggle my diagnosis caused me and my loved ones, along with how I’m doing now that I am melanoma free. To me, those two things are just as important as the story of my diagnosis. If you are unfamiliar with how I got diagnosed, I encourage you to read this piece on the Melanoma Research Foundation website, which shares my story before continuing on with this blog.
Like I mentioned before, a diagnosis affects not only the individual being diagnosed but also the loved ones in their lives. When I found out about my diagnosis, I had to stay strong. I couldn’t show that pain, anger, frustration, and fright that I was feeling. Not because I didn’t feel it, but because I needed to be tough for the people I love. I was eighteen at the time, a senior in high school, and did not understand what was happening to me, and why it was happening to me. I always knew about cancer and how horrific it is, but like most people, I never thought it would happen to me. But it did.
This diagnosis nearly broke my mom. I never saw her so afraid, unsure and just upset. It consumed her, which consumed the rest of our family. I couldn’t let my fear and anger make things worse. I had to keep telling myself not to cry, and not to let my fear of the unknown show so that she could at least see that I knew things were going to be okay, even though I didn’t. Even though I don’t regret bottling up those feelings and pretending I was alright to my family and my friends, I know how psychologically harmful that was for me. Thankfully, once I was melanoma free I was able to go to therapy and let those bottled up emotions out. Therapy helped me move past feeling embarrassed and thinking I am “ugly” due to the scars on my body. It helped me stop wearing a Band-Aid on my thumb even though I was all healed up. It helped me gain the confidence to win Miss Illinois USA, and walk across the Miss USA stage in a bathing suit. And it helps me continue to spread awareness and prevention towards this awful disease.
Although I am melanoma free, and although I’ve gone to therapy, I’d be lying if I said my diagnosis and that scary time in my life didn’t affect me today. Although I am doing much better and feel more confident, I still catch myself covering up my thumb when I talk to people. I still catch myself picking out a shirt that covers the scar across my chest rather than the one that doesn’t. I still catch myself holding my breath every time I go to see my dermatologist for a checkup. Although I am melanoma free, almost every time I have that checkup, I need another biopsy because something looks “off”. Waiting for those results is always excruciating for me, but thankfully they’ve been coming out benign.
I’m very thankful for the position I’m in that allows me to share my story, and spread the message of early detection and prevention. You cannot always prevent cancer, but there is so much you can do that helps. It kills me when I still see my friends going to the tanning salon. I share with them my concern and how I would hope they know better because of my story, but all they say is “they know but need to be tan”. There are so many alternatives. It is safe to go get a spray tan or buy self-tanner. If you have the ability to avoid unnecessary UV rays, then you should be taking it. You should be making sure you’re wearing sunscreen and sun protective clothing when you’re outdoors and making sure you add a dermatologist to the list of doctors you see each year. Early detection possibly saved my life. I know it’s easy to read this and think that it won’t happen to you, but please remember that I didn’t think it would happen to me either, and although I was so lucky, the pain of that diagnosis affects me every single day.
In December of 2013, my wife Terry and I were living in Prague where I had been working for four years. We had returned to the states for Christmas break and were looking forward to seeing and spending time with our family.
I had also scheduled an appointment with my dermatologist as I had a small pimple that turned into a cyst type bump on the top of my head. On December 23, my doctor took a biopsy and three days later I had a diagnosis of Spindle Cell Melanoma, a rare subtype of malignant melanoma. He advised that I get to a specialist immediately as it was large and very deep and needed to be acted on quickly.
Our family realized we needed to educate ourselves about this disease in order to better understand and prepare for the battle ahead. That’s when we discovered the Melanoma Research Foundation (MRF). The knowledge base on melanoma is quite extensive, and frankly a bit overwhelming so the MRF website was an invaluable resource for us.
The process from diagnosis to surgery with daily radiation treatments took three months. As we were planning our return trip back to work in Prague, I discovered a small bump just outside the radiation area. A biopsy confirmed the melanoma had already returned and further testing with a PET scan showed that the melanoma had spread throughout my liver and lungs. I now had Stage IV Metastatic Melanoma.
In 2014, that diagnosis had a very poor prognosis. My doctor said my best chance was a clinical trial that was being offered at Moffitt Cancer Center in Florida. We went back to educating ourselves on what all this meant! Then, armed with more information, I chose to participate in the clinical trial. With that choice, I knew that being a part of cutting-edge research in a clinical trial was just as important as finding a solution for my situation.
From June 2014 to November 2015, our time was filled with long drives to and from treatments, side effects, and a significant adverse reaction that resulted in a hospital stay. But, all of it was in the hopes that we were forging a path to a remarkable outcome.
On November 13th 2015, we finally had a reason to celebrate. We heard the words I wasn’t quite sure I’d ever hear, “Doug, your scans show no evidence of disease”.
Throughout my journey from Stage IV Melanoma to No Evidence of Disease (NED), I felt it was important to help others understand the value of education, research and advocacy for this disease. My experience on a successful—albeit challenging clinical trial—led me to develop a passion for ensuring that the necessary research continues to be funded and findings shared. I am thankful for the scientists, doctors and organizations that bring this disease to the forefront.
In retirement, I’ve taken up a role on the MRF Board of Directors and I am dedicated to helping the organization that is best positioned to educate patients and caregivers fund research grants to find a cure and build a strong, supportive network of advocates. As part of the board, I have the opportunity to contribute to a worthwhile organization that I am certain will make a significant impact in finding a cure for melanoma.